Magnetic Resonance Imaging Abnormalities in Advanced Acute Bilirubin Encephalopathy Highlight Dentato-Thalamo-Cortical Pathways - 24/06/16
Doi : 10.1016/j.jpeds.2016.03.065
Jessica L. Wisnowski, PhD 1, 2, Ashok Panigrahy, MD 1, Michael J. Painter, MD 3, Jon F. Watchko, MD 4, ⁎ 
1 Department of Pediatric Radiology, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh, PA
2 Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA
3 Division of Pediatric Neurology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA
4 Division of Newborn Medicine, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA
∗Reprint requests: Jon F. Watchko, MD, Division of Newborn Medicine, Department of Pediatrics, Magee-Women's Hospital, 300 Halket St, Pittsburgh, PA 15213.Division of Newborn MedicineDepartment of PediatricsMagee-Women's Hospital300 Halket StPittsburghPA15213
Abstract |
A distinct pattern of acute restricted diffusion on magnetic resonance imaging localized to key regions within the dentato-thalamo-cortical pathway was observed early in a term newborn during advanced stages of acute bilirubin encephalopathy. These findings demonstrate that vulnerability to bilirubin toxicity extends across specific neuroanatomic tracts.
Le texte complet de cet article est disponible en PDF.Keywords : kernicterus, hyperbilirubinemia, Rh hemolytic disease, diffusion weighted imaging, apparent diffusion coefficient, cerebellum
Abbreviations : ABE, ADC, CBE, DWI, HIE, MRA, MRI, MRS, MRV, TSB, VA, VL
Plan
| Supported by the Children's Hospital of Pittsburgh Foundation–Ian Harrison Family Fund for Neonatal Neurology Research Program, the Mario Lemieux Foundation, 25 Club of Magee-Women's Hospital, the Rudi Schulte Research Institute, and the National Institutes of Health (K23NS063371). The authors declare no conflicts of interest. |
© 2016
Elsevier Inc. Tous droits réservés.
Vol 174
P. 260-263 - juillet 2016 Retour au numéro
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