Frey Syndrome - 24/06/16

Doi : 10.1016/j.jpeds.2016.03.070

Sibylle Blanc, MD ¹, Thierry Bourrier, MD ¹, Franck Boralevi, MD, PhD ², Dominique Sabouraud-Leclerc, MD ³, Nhân Pham-Thi, MD, PhD ^4,⁵, Laure Couderc, MD ⁶, Antoine Deschildre, MD ⁷, Guy Dutau, MD ⁸, Marc Albertini, MD ^1,⁹, Antoine Tran, MD ¹⁰, Lisa Giovannini-Chami, MD, PhD ^1,⁹
on behalf of the
Frey Syndrome Collaborators^{^∗}
List of additional Frey Syndrome Collaborators is available at www.jpeds.com (Appendix).
Sylvie Pauliat-Desbordes, MD, Marie-Pierre Cordier-Collet, MD, Clément Castella, MD, Laurent Coffinet, MD, Pascale Dumond, MD, François Payot, MD, Michel Moreigne, MD, Monique Gouranton, MD, Marie-Dominique Donnou, MD, Carole Belloy, MD, Yves Turc, MD, Jamal Ghazouani, MD, Michèle Terrisse, MD, Pascaline Grué-Fertin, MD, Claude Rouyer, MD, Caroline Hasselmann, MD, Christine Collet, MD

¹ Pediatric Pulmonology and Allergy Department, Hôpitaux pédiatriques de Nice University Hospital-Lenval, Nice, France
² Pediatric Dermatology Unit, Hôpital Pellegrin-enfants, Bordeaux University Hospital, Bordeaux, France
³ Pediatric Department, Hôpital Américain, Reims, France
⁴ Allergy Department, Institut Pasteur, Paris, France
⁵ University Paris 5 Descartes, Paris, France
⁶ Pediatric Department, Hôpital Charles Nicoles, Rouen, France
⁷ Pediatric Pulmonology and Allergy Department, Clinique de pédiatrie Jeanne de Flandre, Lille University Hospital, Lille, France
⁸ 9 rue Maurice-Alet, Toulouse, France
⁹ Université de Nice-Sophia Antipolis, Nice, France
¹⁰ Pediatric Emergency Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice, France

Abstract

Objective

To describe the features of Frey syndrome (auriculotemporal nerve dysfunction with gustatory flushing) in childhood.

Study design

A multicenter, retrospective, descriptive observational national case series study was conducted with the help of French academic societies. Diagnostic criteria were based on clinical history, and sometimes also on photographs or provocation tests.

Results

Forty-eight cases were identified, with 2 subtypes: 35 unilateral and 13 bilateral. Associated sweating was reported in only 10% of cases. Diagnosis was made in only 20% of children at the first consultation and inappropriate dietary restriction was prescribed for 21%. Instrumented vaginal delivery was significantly associated with unilateral forms (OR [unilateral vs bilateral] = 29; 95% CI 3.99-311.58; P < .001). The outcome was favorable overall with 57% regression, 20% recovery, and only 23% persistence of initial symptoms. Regression was more frequent in unilateral forms (OR = 6.60; 95% CI 1.23-44.04; P = .016), observed in 69% of unilateral forms at a median age of 27 (24-48) months. Recovery predominated in bilateral forms (OR = 0.05; 95% CI 0-0.38; P = .001), observed in 58% of bilateral cases at a median age of 8 (7-9) months.

Conclusions

Frey syndrome in childhood is a rare but benign condition with mild symptoms and a favorable outcome in most cases. Unilateral forms are mostly associated with instrumented delivery. Pediatricians should be familiar with this disorder in order to avoid misdiagnosis, mainly as food allergy, and unnecessary referrals and tests.

Le texte complet de cet article est disponible en PDF.

Keywords : auriculotemporal syndrome, instrumental delivery, food allergy, child, infant

Plan

Methods

Statistical Analyses

Results

Diagnosis and Outcomes

Comparison of Unilateral vs Bilateral Forms

Discussion

The authors declare no conflicts of interest.

Export

Vol 174

P. 211 - juillet 2016 Retour au numéro

Article précédent

Dent Disease in Chinese Children and Findings from Heterozygous Mothers: Phenotypic Heterogeneity, Fetal Growth, and 10 Novel Mutations
Fucheng Li, Zhihui Yue, Tingting Xu, Minghui Chen, Liangying Zhong, Ting Liu, Xiangyi Jing, Jia Deng, Bin Hu, Yuling Liu, Haiyan Wang, Kar N. Lai, Liangzhong Sun, Jinsong Liu, Patrick H. Maxwell, Yiming Wang

| Article suivant

Reportable Bacterial Infections among New York City-Born Infants, 2001-2009
Beth M. Isaac, Abbey Masonbrink, Joseph Kennedy, Sharon K. Greene, Robin R. Hennessy, Jennifer B. Rosen, Lisa Trieu, Stephanie Ngai, Stephen S. Morse, Don Weiss

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Frey Syndrome - 24/06/16

Abstract

Objective

Study design

Results

Conclusions

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL