Semantic memory assessment in 15 patients with amyotrophic lateral sclerosis - 20/05/16

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Abstract |
Introduction |
A total of 30 to 50% of amyotrophic lateral sclerosis patients suffer from cognitive disorders. The aim of the study is to characterize these disorders and to assess semantic memory in non-demented ALS patients. The secondary aim is to look for a link between disease type and neuropsychological characteristics.
Method |
Patients were followed in an ALS center in Dijon. The following neuropsychological tests were used in this study: Folstein test, BREF test, verbal fluency, Isaac test, GRESEM test and TOP 30 test.
Results |
Fifteen ALS patients were included. Nine of them (60%) were suffering from a semantic memory disorder. There was no correlation between ALS characteristics and the semantic memory disorder.
Discussion |
This is the first study to reveal a semantic memory disorder in ALS. This result accentuates the hypothesis that ALS and semantic dementia are two phenotypes of the same degenerative process linked to TDP 43 proteinopathy.
Le texte complet de cet article est disponible en PDF.Keywords : Amyotrophic lateral sclerosis, Semantic memory
Plan
Vol 172 - N° 4-5
P. 307-312 - avril 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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