Cryptococcus tetragattii as a major cause of cryptococcal meningitis among HIV-infected individuals in Harare, Zimbabwe - 20/05/16
, Jacques F. Meis c, d, Valerie J. Robertson bSummary |
Objectives |
HIV-associated cryptococcal meningitis is commonly caused by Cryptococcus neoformans, whilst infections with Cryptococcus gattii sensu lato are historically rare. Despite available studies, little is known about the occurrence of C. gattii sensu lato infections among HIV-infected individuals in Zimbabwe.
Methods |
In a prospective cohort, we investigated the prevalence of C. gattii sensu lato meningitis among HIV-infected patients (n = 74) in Harare, Zimbabwe.
Results |
Of the 66/74 isolates confirmed by molecular characterization, 16.7% (11/66) were found to be C. gattii sensu lato and 83.3% (55/66) C. neoformans sensu stricto. From one patient two phenotypically different C. gattii sensu lato colonies were cultured. The majority (n = 9/12; 75%) of the C. gattii sensu lato isolates were Cryptococcus tetragattii (AFLP7/VGIV), which has been an infrequently reported pathogen. In-hospital mortality associated with C. gattii sensu lato was 36.4%.
Conclusions |
Our data suggests that C. tetragattii (AFLP7/VGIV) is a more common cause of disease than C. gattii sensu stricto (genotype AFLP4/VGI) among patients with HIV-associated cryptococcal meningitis in Harare, Zimbabwe and possibly underreported in sub-Saharan Africa.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Cryptococcus tetragattii is a common cause of disease in HIV-infected subjects. |
• | In-hospital mortality associated with Cryptococcus gattii sensu lato was 36.4%. |
• | Majority of C. gattii sensu lato isolates was found to be mating-type α. |
• | Zimbabwean C. tetragattii isolates are genetically linked to other African isolates. |
• | The ecological niche of this HIV-associated pathogen remains an enigma. |
Keywords : Cryptococcus gattii, Cryptococcus neoformans, Cryptococcus tetragattii, Cryptococcal meningitis, AFLP genotyping, Multilocus sequence typing, Mycological biotyping, HIV infections
Plan
Vol 72 - N° 6
P. 745-752 - juin 2016 Retour au numéro
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