Interferon-gamma release assays in patients with Mycobacterium kansasii pulmonary infection: A retrospective survey - 20/05/16
, Hideaki Nagai , Hirotoshi Matsui , Yoshiko Kawabe , Keita Takeda , Masahiro Kawashima , Junko Suzuki , Nobuharu Ohshima , Kimihiko Masuda , Akira Yamane , Atsuhisa Tamura , Shinobu Akagawa , Ken Ohta Summary |
Objectives |
Interferon-gamma release assays (IGRAs) can be positive in patients infected with Mycobacterium kansasii (M. kansasii), which carries some of Mycobacterium tuberculosis specific antigens adopted for IGRAs. Our aim is to evaluate positive rate and factors associated with positive IGRAs in patients with M. kansasii pulmonary infection.
Methods |
We retrospectively investigated 105 M. kansasii cases in which IGRAs were performed before or ≦14 days after treatment initiation. Clinical characteristics including a history of tuberculosis, radiographic features and laboratory data were collected from medical records.
Results |
Positive rate of each IGRA was 25.9% (15/58) in QuantiFERON TB-Gold (QFT-G), 31.8% (7/22) in QuantiFERON-TB Gold In Tube (QFT-GIT), and 33.3% (7/21) in T-SPOT. TB (T-SPOT). After excluding cases having a history of tuberculosis, positive rate of each IGRA decreased to 19% (8/42) in QFT-G, 20% (3/15) in QFT-GIT, and 18.8% (3/16) in T-SPOT. The multivariate analysis revealed that only previous tuberculosis was significantly associated with positive IGRAs (odds ratio, 4.758; 95% confidence interval, 1.73–13.05; p = 0.002).
Conclusions |
Positive rates of IGRAs were low in patients with M. kansasii, especially in those without previous tuberculosis. M. kansasii pulmonary infection alone might induce less interferon-gamma production with the antigens.
Le texte complet de cet article est disponible en PDF.Highlights |
• | The positive rate of IGRAs in patients with M. kansasii was approximately 30%. |
• | M. kansasii infection induced less activation of IGRAs than tuberculosis infection. |
• | Previous TB is the only factor affecting IGRA positivity in patients with M. kansasii. |
• | The cross-reactivity of TB specific antigens in cases with M. kansasii may be weak. |
Keywords : Interferon-gamma release assays, Mycobacterium kansasii
Plan
Vol 72 - N° 6
P. 706-712 - juin 2016 Retour au numéro
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