Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China - 09/05/16

Doi : 10.1016/j.tube.2016.02.008

Peng Xu ^a,^{^{1
These authors contributed equally to this work.}}, Jie Wu ^b,^{^{1
These authors contributed equally to this work.}}, Chongguang Yang ^a, Tao Luo ^c, Xin Shen ^b, Yangyi Zhang ^b, Chijioke A. Nsofor ^a, Guofeng Zhu ^b,^⁎ , Brigitte Gicquel ^d,^e,^⁎ , Qian Gao ^a,^⁎
^a Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Institute of Biomedical Sciences, Institute of Medical Microbiology, Shanghai Medical College, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China
^b Department of Tuberculosis Control, Shanghai Municipal Center for Disease Control and Prevention, 1380 West Zhong Shan Road, Shanghai 200336, China
^c Laboratory of Infection and Immunity, School of Basic Medical Science, West China Center of Medical Sciences, Sichuan University, Chengdu, Sichuan 610041, China
^d Emerging Bacterial Pathogens Unit, Institut Pasteur of Shanghai, 411 Hefei Road, Shanghai 200025, China
^e Unité de Génétique Mycobactérienne, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris, France

^∗Corresponding author. Tel.: +86 21 5423 7195.^∗∗Corresponding author. Emerging Bacterial Pathogens Unit, Institut Pasteur of Shanghai, 411 Hefei Road, Shanghai 200025, China. Tel.: +86 21 6385 0152.^∗∗∗Corresponding author. Tel.: +86 21 6275 8710.

Summary

Pyrazinamide (PZA) is an important first-line anti-tuberculosis drug, however, there are relatively few available data on PZA resistant (PZA-R) rate in China. From June 2009 to June 2012, we selected 493 isolates from five field settings in China to investigate PZA-R by pncA gene sequencing. The result showed that PZA-R rate was 1.0% (2/196) among pan-susceptible isolates, 3.1% (4/130) among isoniazid (INH) mono-resistant isolates, 14.0% (6/43) among rifampin (RIF) mono-resistant isolates and 43.5% (54/124) among multidrug resistant (MDR) isolates. MDR tuberculosis (TB), RIF mono-resistance, and retreatment were found to be risk factors for PZA-R. Newly diagnosed PZA-R TB patients and clustered isolates with identical pncA mutations indicate that transmission of PZA-R isolates plays an important role in emergence of PZA-R TB. The results suggest that, it is necessary to conduct PZA susceptibility test among MDR isolates and modify the treatment regimens accordingly.

Le texte complet de cet article est disponible en PDF.

Keywords : Mycobacterium tuberculosis, Pyrazinamide resistance, Transmission

Plan

Introduction

Materials and methods

Study population and isolates

Drug susceptibility test

Statistical analyses

Results

Characteristics of the patients and isolates

Mutations types and prevalence of PZA resistance

Risk factors of PZA resistance

Transmission of PZA-R isolates

Discussion

Conclusion

Export

Vol 98

P. 56-61 - mai 2016 Retour au numéro

Article précédent

Boosting BCG with inert spores improves immunogenicity and induces specific IL-17 responses in a murine model of bovine tuberculosis
M. Carmen Garcia-Pelayo, Daryan A. Kaveh, Laura Sibley, Paul R. Webb, Naomi C. Bull, Simon M. Cutting, Philip J. Hogarth

| Article suivant

Elevated serum 25-hydroxy (OH) vitamin D levels are associated with risk of TB progression in Gambian adults
Olumuyiwa Owolabi, Schadrac Agbla, Patrick Owiafe, Simon Donkor, Toyin Togun, Abdou K. Sillah, Martin O.C. Ota, Jayne S. Sutherland

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Prevalence and transmission of pyrazinamide resistant Mycobacterium tuberculosis in China - 09/05/16

Summary

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL