The Eocene clastic systems of the Jaca foreland Basin (southern Pyrenees) allow us to identify changes in sediment composition through time. We provide new data on sediment composition and sources of the northern Jaca basin, whose stratigraphic evolution from Middle Lutetian deep-marine to Priabonian alluvial systems record a main reorganization in the active Pyrenean prowedge. Petrological analysis shows that the Banastón and the Lower Jaca turbidite systems (Middle–Upper Lutetian) were fed from an eastern source, which dominated during the sedimentation of the Hecho Group turbidites. In contrast, the upper part of the Jaca turbidite systems (Lutetian–Bartonian transition) records an increase in the number of subvolcanic rock and hybrid-sandstone fragments (intrabasinal and extrabasinal grains) being the first system clearly fed from the north. This change is interpreted as associated with an uplifting of the Eaux-Chaudes/Lakora thrust sheet in the northern Axial Zone. The Middle Bartonian Sabiñánigo sandstone derives from eastern and northeastern source areas. In contrast, the overlying Late Bartonian–Early Priabonian Atarés delta records sediment input from the east. The Santa Orosia alluvial system records a new distinct compositional change, with a very high content of hybrid-sandstone clasts from the Hecho Group, again from a northern provenance. Such cannibalized clasts were sourced from newly emerged areas of the hinterland, associated with the basement-involved Gavarnie thrust activity in the Axial Zone.