Differential binding of CREB, USF, and c-Myc to the calreticulin human specific –220C may be linked with the evolution of higher brain functions in human - 13/04/16
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Résumé |
Introduction |
We have previously reported a human-specific nucleotide in the promoter sequence of the calreticulin (CALR) gene at position –220C, which is the site of action of valproic acid.
Objectives |
Reversion of this nucleotide to the ancestral type, –220A, co-occurs with severe deficit in higher brain cognitive functions.
Aims |
In the current study, we compare the pattern of protein binding between –220C and –220A.
Methods |
Antibodies reactive against transcription factors CREB, USF, and c-Myc were used to identify the specific proteins involved in complexes with DNA using electrophoretic mobility shift assay (EMSA).
Results |
Significant increase was observed in the overall protein complexes binding to the –220C allele vs. –220A. The transcription factors, CREB, USF, and c-Myc, were differentially bound to –220C, represented by supershifts.
Conclusions |
We propose that differential binding of CREB, USF, and c-Myc to CALR nucleotide –220C may be linked with the evolution of higher brain functions in human.
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Vol 33 - N° S
P. S465-S466 - mars 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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