Collagen-based biomaterials for ibuprofen delivery - 07/04/16
, Mihaela Violeta Ghica bBienvenue sur EM-consulte, la référence des professionnels de santé.
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Abstract |
Drug delivery systems based on collagen sponges have increasingly become interesting materials for different medical applications. In this paper we present the obtaining, characterization and in vitro release of ibuprofen from collagen-based biomaterials in the form of sponges. The structural and morphological characteristics of these materials were investigated by infrared spectroscopy (FT-IR) and water uptake tests. Collagenase degradation, anti-inflammatory drug release and the kinetic mechanism are also discussed. The results obtained suggest that these new systems based on collagen have good potential for sustained release of analgesic and anti-inflammatory agents such as ibuprofen and the combination of collagen and ibuprofen as a sponge is a promising therapeutic method for the treatment of dental problems.
Le texte complet de cet article est disponible en PDF.Keywords : Collagen sponges, FT-IR analysis, Ibuprofen, Kinetic profile, Dentistry
Plan
Vol 19 - N° 3
P. 390-394 - mars 2016 Retour au numéro
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