Factors associated with failure to complete adjuvant chemotherapy in pancreatic cancer - 17/03/16
, Toshihiro Tanaka, M.D. b, Shoichi Kinoshita, M.D. a, Minako Nagai, M.D. a, Satoshi Nishiwada, M.D. a, Hideyuki Nishiofuku, M.D. b, Chiho Ohbayashi, M.D. c, Kimihiko Kichikawa, M.D. b, Yoshiyuki Nakajima, M.D. aAbstract |
Background |
The importance of completing adjuvant chemotherapy in pancreatic cancer is becoming recognized. However, the clinicopathological factors associated with failure to complete adjuvant chemotherapy remain unclear.
Methods |
A total of 135 patients were analyzed to identify the factors associated with failure to complete adjuvant chemotherapy.
Results |
Ninety patients completed planned adjuvant chemotherapy, whereas 45 patients failed to complete adjuvant chemotherapy. Lower preoperative prognostic nutritional index, intraoperative blood transfusion, and organ and/or space surgical site infection, and advanced tumor stage were associated with failure to complete adjuvant chemotherapy. Neoadjuvant chemoradiotherapy was associated with significantly lower prognostic nutritional index, less incidence of organ and/or space surgical site infection, and earlier tumor stage, suggesting the conflicting effects of neoadjuvant chemoradiotherapy on completing adjuvant chemotherapy.
Conclusions |
Several clinicopathological factors including patient conditions and perioperative events were associated with failure to complete adjuvant chemotherapy.
Le texte complet de cet article est disponible en PDF.Highlights |
• | Completing adjuvant chemotherapy is critical for pancreatic cancer. |
• | Several factors contribute to the failure to complete adjuvant chemotherapy. |
• | Neoadjuvant chemoradiotherapy has the conflicting effects on adjuvant chemotherapy. |
Keywords : Pancreatic cancer, Adjuvant chemotherapy, Prognosis, Recurrence
Plan
| There were no relevant financial relationships or any sources of support in the form of grants, equipment, or drugs. |
|
| The authors declare no conflicts of interest. |
Vol 211 - N° 4
P. 787-792 - avril 2016 Retour au numéro
Article précédent
- Intraoperative management of renal gunshot injuries: is mandatory exploration of Gerota’s fascia necessary?
- Jack Rostas, Jon D. Simmons, Mohommad A. Frotan, Sidney B. Brevard, Richard P. Gonzalez
- Is fear for postoperative cardiopulmonary complications after bariatric surgery in patients with obstructive sleep apnea justified? A systematic review
- Christel A.L. de Raaff, Usha K. Coblijn, Nico de Vries, Bart A. van Wagensveld
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?