Effect of proton pump inhibitors and antibiotics on the gut microbiome of hospitalised older persons - 09/03/16
Doi : 10.1016/j.jinf.2016.01.015
Caoilfhionn O'Donoghue ⁎ 
Department of Medicine for the Older Person, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland
∗Corresponding author. Tel.: +353 868169722.
Katie Solomon
University of Exeter, College of Life and Environmental Science, Geoffrey Pope Building, Exeter EX44QD, United Kingdom
Lynda Fenelon
Department of Microbiology, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland
Fidelma Fitzpatrick
Health Protection Surveillance Centre, 25–27 Middle Gardiner Street, Dublin 1, Ireland
Lorraine Kyne
Department of Medicine for the Older Person, Mater Misericordiae University Hospital, Eccles Street, Dublin 7, Ireland
Highlights |
• | Clostridium difficile infection causes significant morbidity and mortality. |
• | Proton pump inhibitors have been associated with Clostridium difficile infection. |
• | We examined the effect of antibiotics and PPIs on the faecal microbiome. |
• | We found PPIs was associated with increased gut microbiome species diversity. |
• | PPIs appeared to attenuate the negative effects of antibiotics on the gut microbiome. |
Plan
© 2016
The British Infection Association. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 72 - N° 4
P. 498-500 - avril 2016 Retour au numéro
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