Enteral Feeding with Human Milk Decreases Time to Discharge in Infants following Gastroschisis Repair - 25/02/16
Abstract |
Objective |
To assess the effect of enteral feeding with human milk on the time from initiation of feeds to discharge after gastroschisis repair through review of a multi-institutional database.
Study design |
Infants who underwent gastroschisis repair between 1997 and 2012 with data recorded in the Pediatrix Medical Group Clinical Data Warehouse were categorized into 4 groups based on the percentage of days fed human milk out of the number of days fed enterally. Cox proportional hazards regression modeling was performed to determine the adjusted effect of human milk on the time from initiation of feeds to discharge.
Results |
Among 3082 infants, 659 (21%) were fed human milk on 0% of enteral feeding days, 766 (25%) were fed human milk on 1%-50% of enteral feeding days, 725 (24%) were fed human milk on 51%-99% of enteral feeding days, and 932 (30%) were fed human milk on 100% of enteral feeding days. Following adjustment, being fed human milk on 0% of enteral feeding days was associated with a significantly increased time to discharge compared with being fed human milk on 100% of enteral feeding days (hazard ratio [HR] for discharge per day, 0.46; 95% CI, 0.40-0.52). The same was found for infants fed human milk on 1%-50% of enteral feeding days (HR, 0.37; 95% CI, 0.32-0.41) and for infants fed human milk on 51%-99% of enteral feeding days (HR, 0.51; 95% CI, 0.46-0.57).
Conclusion |
The use of human milk for enteral feeding of infants following repair of gastroschisis significantly reduces the time to discharge from initiation of feeds.
Le texte complet de cet article est disponible en PDF.Keyword : HR, NEC, NICU
Plan
| Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD; HHSN275201000003I for the Pediatric Trials Network and 1R25HD076475). B.G. receives support from the National Institutes of Health–funded Cardiothoracic Surgery Trials Network (5U01HL088953-05). M.L. receives support from the US government for his work in pediatric and neonatal clinical pharmacology (HHSN267200700051C under the Best Pharmaceuticals for Children Act [PI: Daniel K. Benjamin Jr]) and NICHD (K23HD068497). P.S. receives salary support for research from the National Center for Advancing Translational Sciences (UL1TR001117), NICHD (HHSN2752010000031 and 1R01-HD081044-01), the Food and Drug Administration (1R18-FD005292-01), and Cempra Pharmaceuticals (subaward to HHS0100201300009C); and serves as a paid consultant for AbbVie, Astellas Pharma US, GlaxoSmithKline, and MissionPharma. C.H. receives salary support from the National Center for Advancing Translational Sciences (UL1TR001117). The other authors declare no conflicts of interest. |
Vol 170
P. 85-89 - mars 2016 Retour au numéro
Article précédent
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