Kidney Stones as an Underrecognized Clinical Sign in Pediatric Cushing Disease - 25/02/16

Doi : 10.1016/j.jpeds.2015.11.045

Sara H. Rahman, BA ^1,², Georgios Z. Papadakis, MD ³, Margaret F. Keil, PhD, CRNP ¹, Fabio R. Faucz, PhD ¹, Maya B. Lodish, MD ^1,^⁎^{^{∗
Contributed equally.}} , Constantine A. Stratakis, MD ^1,^{^{∗
Contributed equally.}}
¹ Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD
² Frank H. Netter School of Medicine, Quinnipiac University, North Haven, CT
³ Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, MD

^∗Reprint requests: Maya B. Lodish, MD, Program Director, Pediatric Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bldg 10, Rm 9D42, 10 Center Dr, MSC 1830, Bethesda, MD 20814-1830.Pediatric EndocrinologyEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentBldg 10, Rm 9D4210 Center Dr, MSC 1830BethesdaMD20814-1830

Abstract

Objective

To investigate the prevalence of kidney stones in a population of children with Cushing disease (CD) and to compare it with the prevalence of kidney stones in healthy children.

Study design

Clinical and biochemical data from 139 pediatric patients with CD (68 females, 71 males) were analyzed retrospectively. Computed tomography scans were reviewed for kidney stones.

Results

Among 139 patients, 27 with CD (19.4%) had either radiographic evidence and/or a history of kidney stones. Those with kidney stones had higher urine free cortisol (P = .008) and transsphenoidal surgery at an older age (P = .007). The average urinary calcium/creatinine ratio was elevated in patients with CD (0.22 ± 0.11). The prevalence of kidney stones was higher in children with CD than in normal children (19.42% vs 1.0%; P < .001).

Conclusion

Our results illustrate that kidney stones are an underestimated complication of pediatric CD, especially when compared with the prevalence of nephrolithiasis in the general pediatric population. Long-term consequences for kidney function are not known and need to be studied.

Le texte complet de cet article est disponible en PDF.

Keyword : ACTH, Ca/Cr, CD, CS, CT, MEN1, MRI, NIH, TSS, UFC

Plan

The authors declare no conflicts of interest.

Export

Vol 170

P. 273 - mars 2016 Retour au numéro

Article précédent

Treatment of Vitamin D Deficiency in Predominantly Hispanic and Black Adolescents: A Randomized Clinical Trial
Hina J. Talib, Tulasi Ponnapakkam, Robert Gensure, Hillel W. Cohen, Susan M. Coupey

| Article suivant

A Prospective Natural History Study of Mucopolysaccharidosis Type IIIA
Elsa G. Shapiro, Igor Nestrasil, Kathleen A. Delaney, Kyle Rudser, Victor Kovac, Nitin Nair, Charles W. Richard, Patrick Haslett, Chester B. Whitley

Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.

Déjà abonné à cette revue ?

connectez-vous ou créez un compte

Kidney Stones as an Underrecognized Clinical Sign in Pediatric Cushing Disease - 25/02/16

Abstract

Objective

Study design

Results

Conclusion

Plan

Export citations

Fichier

Contenu

Accès rapides

Mon compte

Aide & support

Plateformes Elsevier Masson

Déclaration CNIL