Surgery and hormone therapy trends in octogenarians with invasive breast cancer - 24/02/16
Abstract |
Background |
There has been a trend toward minimizing surgery in elderly women with estrogen receptor-positive (ER+) breast cancer.
Methods |
Using the National Cancer Data Base, we selected 95,357 women ≥80 years with invasive, ER+ breast cancer. Chi-square test and logistic regression were used to analyze trends in surgery and hormone therapy.
Results |
From 2004 to 2012, 90% of women were treated with surgery first and 10% were treated with primary nonoperative management. Of those undergoing nonoperative management, 72% received endocrine therapy and 27% had no treatment. The rate of primary nonoperative treatment doubled from 7% in 2004 to 14% in 2012. Multivariate logistic regression adjusted for patient, facility, and tumor factors identified more advanced clinical stage, older age, African-American race, and treatment at Academic facilities as independent predictors of receiving primary nonsurgical management.
Conclusions |
There has been an increase over time in primary nonoperative management of ER+ breast cancer in octogenarians.
Le texte complet de cet article est disponible en PDF.Keywords : Primary endocrine therapy, Hormone therapy, Breast cancer, Elderly
Plan
| There were no relevant financial relationships or any sources of support in the form of grants, equipment, or drugs. |
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| The authors declare no conflicts of interest. |
Vol 211 - N° 3
P. 541-545 - mars 2016 Retour au numéro
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