Arterial spin labeling in clinical pediatric imaging - 10/02/16

Doi : 10.1016/j.diii.2015.09.001

M. Proisy ^a,^b,^⁎ , B. Bruneau ^a, C. Rozel ^a, C. Tréguier ^a, K. Chouklati ^a, L. Riffaud ^c, P. Darnault ^a, J.-C. Ferré ^b,^d
^a Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France
^b Inserm VisAGeS unité/projet U746, UMR 6074, Irisa, université Rennes 1, 35043 Rennes cedex, France
^c Department of Pediatric Neurosurgery, CHU de Rennes, 2, rue Henri-Le-Guillou, 35033 Rennes cedex 9, France
^d Department of Radiology, hôpital Pontchaillou, CHU de Rennes, 2, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France

^⁎Corresponding author at: Department of Radiology, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.

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Abstract

Arterial spin labeling (ASL) perfusion-weighted magnetic resonance imaging is the only approach that enables direct and non-invasive quantitative measurement of cerebral blood flow in the brain regions without administration of contrast material and without radiation. ASL is thus a promising perfusion imaging method for assessing cerebral blood flow in the pediatric population. Concerning newborns, there are current limitations because of their smaller brain size and lower brain perfusion. This article reviews and illustrates the use of ASL in pediatric clinical practice and discusses emerging cerebral perfusion imaging applications for children due to the highly convenient implementation of the ASL sequence.

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Keywords : Arterial spin labeling, Children, Brain perfusion, MRI

Abbreviations : AIS, ASL, CASL, PASL, pCASL, ATT, AVM, CBF, CTP, DSC, DWI, MRI, PC MRI, PET, PLD, PRES, SNR, T1b