Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study - 07/01/16
, Ane Johannessen, PhD a, Luca Puggini, MSc b, Bryndís Benediktsdóttir, MD, PhD c, Randi J. Bertelsen, PhD d, Ersilia Bifulco, PhD a, e, Shyamali C. Dharmage, MD, PhD f, Julia Dratva, MD, MPH g, h, Karl A. Franklin, MD, PhD i, Thórarinn Gíslason, MD, PhD c, j, Mathias Holm, MD, PhD k, Deborah Jarvis, MD, PhD l, Bénédicte Leynaert, PhD m, Eva Lindberg, MD, PhD n, Andrei Malinovschi, MD, PhD o, Ferenc Macsali, MD, PhD p, Dan Norbäck, MD, PhD q, Ernst R. Omenaas, MD, PhD a, Francisco J. Rodríguez, PhD r, Eirunn Saure, MD d, Vivi Schlünssen, MD, PhD s, Torben Sigsgaard, MD, PhD s, Trude D. Skorge, MD, PhD d, Gunilla Wieslander, MD, PhD q, Elisabeth Zemp, MD, PhD g, h, Cecilie Svanes, MD, PhD d, Steinar Hustad, MD, PhD a, e, Francisco Gómez Real, MD, PhD a, pAbstract |
Background |
There is limited and conflicting evidence on the effect of menopause on asthma.
Objectives |
We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.
Methods |
The Respiratory Health in Northern Europe study provided questionnaire data pertaining to respiratory and reproductive health at baseline (1999-2001) and follow-up (2010-2012). The study cohort included women aged 45 to 65 years at follow-up, without asthma at baseline, and not using exogenous hormones (n = 2322). Menopausal status was defined as nonmenopausal, transitional, early postmenopausal, and late postmenopausal. Associations with asthma (defined by the use of asthma medication, having asthma attacks, or both) and respiratory symptoms scores were analyzed by using logistic (asthma) and negative binomial (respiratory symptoms) regressions, adjusting for age, body mass index, physical activity, smoking, education, and study center.
Results |
The odds of new-onset asthma were increased in women who were transitional (odds ratio, 2.40; 95% CI, 1.09-5.30), early postmenopausal (odds ratio, 2.11; 95% CI, 1.06-4.20), and late postmenopausal (odds ratio, 3.44; 95% CI, 1.31-9.05) at follow-up compared with nonmenopausal women. The risk of respiratory symptoms increased in early postmenopausal (coefficient, 0.40; 95% CI, 0.06-0.75) and late postmenopausal (coefficient, 0.69; 95% CI, 0.15-1.23) women. These findings were consistent irrespective of smoking status and across study centers.
Conclusions |
New-onset asthma and respiratory symptoms increased in women becoming postmenopausal in a longitudinal population-based study. Clinicians should be aware that respiratory health might deteriorate in women during reproductive aging.
Le texte complet de cet article est disponible en PDF.Key words : Amenorrhea, asthma, estrogens, longitudinal, menopausal asthma, menopause, respiratory symptoms, reproductive aging, Respiratory Health in Northern Europe, sex hormones
Abbreviations used : BMI, HRT, STRAW
Plan
| K.T. has received a PhD scholarship from the Norwegian Research Council (project no. 228174). This project also funded the estrogen measurements. Respiratory Health in Northern Europe (RHINE) was supported financially by the Norwegian Research Council (grant no. 214123), the Bergen Medical Research Foundation, the Western Norwegian Regional Health Authorities (grant nos. 911 892 and 911 631), the Norwegian Labour Inspection, the Norwegian Asthma and Allergy Association, the Faculty of Health of Aarhus University (project no. 240008), the Wood Dust Foundation (project no. 444508795), the Danish Lung Association, the Swedish Heart-Lung Foundation, the Vårdal Foundation for Health Care Science and Allergy Research, the Swedish council for working life and social research, the Bror Hjerpstedt Foundation, the Swedish Asthma and Allergy Association, the Icelandic Research Council, and the Estonian Science Foundation (grant no. 4350). |
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| Disclosure of potential conflict of interest: K. Triebner has received grants from the Norwegian Research Council (project no. 228174, grant no. 214123), the Bergen Medical Research Foundation, the Western Norwegian Regional Health Authorities (grant nos. 911 892 and 911 631), the Norwegian Labour Inspection, the Norwegian Asthma and Allergy Association, the Faculty of Health of Aarhus University (project no. 240008), the Wood Dust Foundation, the Danish Lung Association, the Swedish Heart and Lung Foundation, the Vårdal Foundation for Health Care Science and Allergy Research, the Swedish Council for Working Life and Social Research, Bror Hjerpstedt Foundation, the Swedish Asthma and Allergy Association, the Icelandic Research Council, and the Estonian Science Foundation (grant no. 4350) and has received travel support from EPINOR. L. Puggini has received grants from the Norwegian Research Council (project no. 228174, grant no. 214123) and NUI Maynooth and has been employed by Google. B. Benediktsdóttir and E. Saure have received grants from the Norwegian Research Council (project no. 228174, grant no. 214123), the Bergen Medical Research Foundation, the Western Norwegian Regional Health Authorities (grant nos. 911 892 and 911 631), the Norwegian Labour Inspection, the Norwegian Asthma and Allergy Association, the Faculty of Health of Aarhus University (project no. 240008), the Wood Dust Foundation, the Danish Lung Association, the Swedish Heart and Lung Foundation, the Vårdal Foundation for Health Care Science and Allergy Research, the Swedish Council for Working Life and Social Research, Bror Hjerpstedt Foundation, the Swedish Asthma and Allergy Association, the Icelandic Research Council, and the Estonian Science Foundation (grant no. 4350). T. Gislason has received grants from the University of Iceland and Landspitali University Hospital. D. Jarvis has received a grant from the Medical Research Council. F. J. Rodriguez is employed by the Department of Applied Mathematics at Malaga University. V. Schlünssen has received a grant from the Faculty of Health of Aarhus University (project no. 240008), has received a consulting fee or honorarium from the Wood Dust Foundation and has consultant arrangements with the Danish National Board of Industrial Injuries and the Danish Labour Union HK Denmark. F. Gómez Real has received a grant, travel support, and provision of writing assistance, medicines, equipment, or administrative support for this work from the Norwegian Research Council. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 137 - N° 1
P. 50 - janvier 2016 Retour au numéro
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