IL-10–producing forkhead box protein 3–negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus - 07/01/16
Doi : 10.1016/j.jaci.2015.06.044
Federica Facciotti, PhD a, Nicola Gagliani, PhD c, ∗, Barbara Häringer, PhD b, d, ∗, Johanna Sophie Alfen, PhD a, e, ∗, Alessandra Penatti, MD f, Stefano Maglie, BSc a, Moira Paroni, PhD a, Andrea Iseppon, BSc c, Monica Moro, PhD a, Maria Cristina Crosti, BSc a, Katharina Stölzel, MD d, Chiara Romagnani, PhD b, Gabriella Moroni, MD h, Francesca Ingegnoli, MD e, Sara Torretta, MD i, Lorenzo Pignataro, MD i, Andrea Annoni, PhD j, Fabio Russo, PhD j, Massimiliano Pagani, PhD a, g, Sergio Abrignani, PhD a, f, Pierluigi Meroni, MD f, Richard Flavell, PhD c, k, Jens Geginat, PhD a 
a INGM–National Institute of Molecular Genetics “Romeo ed Enrica Invernizzi”, Milan, Italy
b DRFZ–German Rheumatology Research Institute, Berlin, Germany
c Department of Immunobiology, Yale University, New Haven, Conn
k Howard Hughes Medical Institute School of Medicine, Yale University, New Haven, Conn
d Medical Department, Division of Rheumatology and Clinical Immunology, Charité Universitätsmedizin, Berlin, Germany
e Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, University of Milan, Milan, Italy
f DISCCO–Department of Clinical Science and Community Health, Universitá degli Studi di Milano, Milan, Italy
g Department of Medical Biotechnology and Translational Medicine, Universitá degli Studi di Milano, Milan, Italy
h Unità operativa di Nefrologia e Dialisi, Milan, Italy
i Otorinolaringoiatria Fondazione Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
j San Raffaele Telethon Institute for Gene Therapy, and the Division of Regenerative Medicine, Stem Cells and Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy
| Supported by the Deutsche Forschungsgemeinschaft (SFB650TPN01 to J.G.), a long-term EMBO fellowship to N.G. and a short-term EMBO fellowship to F.F, the Cariplo Foundation (grant no. 2009-3328 to J.G.) and the Italian Lupus Foundation “Gruppo LES Italiano.” |
|
| Disclosure of potential conflict of interest: N. Gagliani has received research support from the Cancer Research Institute. J. S. Alfen, A. Pennatti, S. Maglie, M. Paroni, M. Moro, M. C. Crosti, K. Stölzel, G. Moroni, F. Ingegnoli, S. Torreta, L. Pignataro, M. Pagani, S. Abrignani, P. Meroni, and J. Geginat have received research and travel support from Gruppo Italiano per la lotta contro il Lupus Eritematoso Sistemico and Fondazione Cariplo and have had a research project (“Immune-monitoring of lupus patients undergoing anti-Il-10 therapy”) sponsored by Biotest AG. R. Flavell has received research support from Fondazione Cariplo and the Howard Hughes Medical Institute. The rest of the authors declare that they have no relevant conflicts of interest. |
© 2015
American Academy of Allergy, Asthma & Immunology. Publié par Elsevier Masson SAS. Tous droits réservés.
Vol 137 - N° 1
P. 318 - janvier 2016 Retour au numéro
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