Neonatal adiposity increases the risk of atopic dermatitis during the first year of life - 07/01/16
Abstract |
Background |
Early nutrition and adiposity have been linked to atopic dermatitis (AD) development.
Objective |
We sought to describe risk factors for AD in the first year of life in infants participating in the Cork BASELINE birth cohort study (n = 1537).
Methods |
Prospective data on early-life events, infant feeding, and nutritional and environmental exposures were collected at 15 weeks' gestation, birth, and 2, 6, and 12 months of age. Body composition was assessed by using air displacement plethysmography at day 2 and 2 months. The primary outcome, persistent AD, was determined if the UK Working Party Diagnostic Criteria were satisfied at both 6 and 12 months.
Results |
At 6 and 12 months, the point prevalence of AD was 14.2% (99% CI, 10.5% to 17.8%) and 13.7% (99% CI, 10.3% to 17.6%), respectively; 7.5% (99% CI, 5.0% to 9.9%) of infants had AD at both 6 and 12 months of age. At hospital discharge, 35% of infants were exclusively breast-fed, decreasing to 14% by 2 months. Complementary feeding was commenced at a median of 19 weeks (interquartile range, 17-22 weeks; 19% at <17 weeks and 6% at ≥26 weeks). Median fat mass at day 2 was 0.35 kg (interquartile range, 0.25-0.48 kg). A parental history of atopic disease was self-reported by 43% of mothers and 34% of fathers. Risk factors for AD at 6 and 12 months were maternal atopy (adjusted odds ratio, 2.99; 99% CI, 1.35-6.59; P = .0004) and fat mass of the 80th percentile or greater at day 2 (adjusted odds ratio, 2.31; 99% CI, 1.02-2.25; P = .009).
Conclusion |
This is the first report of neonatal adiposity as a predictor of AD at 6 and 12 months of age in a well-characterized atopic disease–specific birth cohort.
Le texte complet de cet article est disponible en PDF.Key words : Atopic dermatitis, eczema, infant, body composition, vitamin D, infant feeding
Abbreviations used : AD, BASELINE, BMI, IQR, 25(OH)D, OR, SCOPE, UKWPDC
Plan
| The National Children's Research Centre (NCRC) is the primary funding source for the ongoing Cork Babies After SCOPE: Evaluating the Longitudinal Impact Using Neurological and Nutritional Endpoints (BASELINE) birth cohort. Additional support came from the UK Food Standards Agency (FSA) (grant no. T07060). The SCOPE Ireland Study was funded by the Health Research Board of Ireland (CSA 02/2007). L.C.K., M.K., and D.M.M. are PIs in the Science Foundation Ireland funded INFANT Research Centre (grant no. 12/RC/2272). S.M.O'D. is supported by a grant to M.K. from the European Commission under the Seventh Framework (ODIN, GA 613977 Food-based Solutions for Optimal Vitamin D Nutrition and Health through the Lifecycle) and by a grant to M.K. and J.O'B.H. from the European Commission under the Seventh Framework (iFAAM; GA 312147 Integrated Approaches to Food Allergen and Allergy Risk Management). |
|
| Disclosure of potential conflict of interest: S. M. O'Donovan has received research support from the European Union FP7 (ODIN, GA 613977; iFAAM; GA 312147). J. O'B. Hourihane has received research support from the Food Standards Agency and the National Children's Research Centre Ireland and has received lecture fees from Thermo Fisher. L. C. Kenny has provided expert testimony in several ongoing medical negligence cases, has received research funding to support the Centre that she directs (www.infantcentre.ie), and has received royalties as the editor of several textbooks (www.infantcentre.ie). M. Kiely has received research support from the National Children's Research Centre, Crumlin, Dublin, for establishment of the cohort; from iFAAM (EC grant no. 312147) for serving as a coinvestigator; and from ODIN (EC grant no. 613977) for serving as principal investigator and project coordinator. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 137 - N° 1
P. 108-117 - janvier 2016 Retour au numéro
Article précédent
- Low E-prostanoid 2 receptor levels and deficient induction of the IL-1?/IL-1 type I receptor/COX-2 pathway: Vicious circle in patients with aspirin-exacerbated respiratory disease
- Liliana Machado-Carvalho, Margarita Martín, Rosa Torres, Marta Gabasa, Isam Alobid, Joaquim Mullol, Laura Pujols, Jordi Roca-Ferrer, Cesar Picado
- Diverse activation and differentiation of multiple B-cell subsets in patients with atopic dermatitis but not in patients with psoriasis
- Tali Czarnowicki, Juana Gonzalez, Kathleen M. Bonifacio, Avner Shemer, Peng Xiangyu, Norma Kunjravia, Dana Malajian, Judilyn Fuentes-Duculan, Hitokazu Esaki, Shinji Noda, Yeriel Estrada, Hui Xu, Xiuzhong Zheng, James G. Krueger, Emma Guttman-Yassky
Bienvenue sur EM-consulte, la référence des professionnels de santé.
L’accès au texte intégral de cet article nécessite un abonnement.
Déjà abonné à cette revue ?