Paraoxanase as an indicator of myocardial ischemia and its utility in determining extension of ischemia - 14/12/15
, Ramazan Kocabaş, MD b , Tolga Doğan, MD c , Hacı Kemal Erdemli, MD b , Mücahit Yetim, MD c Abstract |
Background |
The aim of this study was to investigate Paraoxanase 1 (PON-1) activity in patients with ST-elevated and non–ST-elevated acute myocardial infarction (AMI) and to determine its correlation with Gensini scores (GSs).
Methods |
A total of 109 patients with AMI and 58 healthy subjects as control group were included in the study. Patients were divided into 2 subgroups as ST-elevated and non–ST-elevated AMI patients (Group I and II, respectively). Controls were named as Group III. PON-1 activity was determined on admission to emergency department for each group. In addition, GSs for patient groups were determined. Then, groups were compared according to their results.
Results |
PON-1 levels in Group I and II were significantly lower when compared to Group III. Median GSs for Group I and II were 60 and 64, respectively. The cut-off value of PON-1 for diagnosis of AMI was ≤180 U/L, which was identified by receiver characteristics receiver curve analysis. However, we could not determine a significant relationship between serum PON-1 levels and GSs in patients with AMI.
Conclusion |
PON-1 levels measured on admission to emergency department may be used to rule out AMI. PON-1 levels in AMI patients are found to be inefficient in determining extension of ischemia measured by GS.
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| ☆ | Conflict of interests: None to declare. |
| ☆☆ | Funding: None to declare. |
Vol 34 - N° 1
P. 45-48 - janvier 2016 Retour au numéro
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