Evolution pathways of IgE responses to grass and mite allergens throughout childhood - 04/12/15
Abstract |
Background |
Little is known about longitudinal patterns of the development of IgE to distinct allergen components.
Objective |
We sought to investigate the evolution of IgE responses to allergenic components of timothy grass and dust mite during childhood.
Methods |
In a population-based birth cohort (n = 1184) we measured IgE responses to 15 components from timothy grass and dust mite in children with available samples at 3 time points (ages 5, 8, and 11 years; n = 235). We designed a nested, 2-stage latent class analysis to identify cross-sectional sensitization patterns at each follow-up and their longitudinal trajectories. We then ascertained the association of longitudinal trajectories with asthma, rhinitis, eczema, and lung function in children with component data for at least 2 time points (n = 534).
Results |
Longitudinal latent class analysis revealed 3 grass sensitization trajectories: (1) no/low sensitization; (2) early onset; and (3) late onset. The early-onset trajectory was associated with asthma and diminished lung function, and the late-onset trajectory was associated with rhinitis. Four longitudinal trajectories emerged for mite: (1) no/low sensitization; (2) group 1 allergens; (3) group 2 allergens; and (3) complete mite sensitization. Children in the complete mite sensitization trajectory had the highest odds ratios (ORs) for asthma (OR, 7.15; 95% CI, 3.80-13.44) and were the only group significantly associated with comorbid asthma, rhinitis, and eczema (OR, 5.91; 95% CI, 2.01-17.37). Among children with wheezing, those in the complete mite sensitization trajectory (but not other longitudinal mite trajectories) had significantly higher risk of severe exacerbations (OR, 3.39; 95% CI, 1.62-6.67).
Conclusions |
The nature of developmental longitudinal trajectories of IgE responses differed between grass and mite allergen components, with temporal differences (early vs late onset) dominant in grass and diverging patterns of IgE responses (group 1 allergens, group 2 allergens, or both) in mite. Different longitudinal patterns bear different associations with clinical outcomes, which varied by allergen.
Le texte complet de cet article est disponible en PDF.Key words : IgE, childhood, component-resolved diagnostics, latent class analysis, allergens, dust mite, timothy grass, asthma, wheeze, rhinitis
Abbreviations used : ATS, CRD, eNO, FVC, ISAC, ISU, LCA, MAAS, OR, sIgE
Plan
| MAAS is supported by grants from the J P Moulton Charitable Foundation and Medical Research Council (MRC) grants G0601361 and MR/K002449/1. This study was partly supported by MRC Health eResearch Centre (HeRC) grant MR/K006665/1. |
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| Disclosure of potential conflict of interest: This study was partly supported by an MRC Health eResearch Centre (HeRC) grant (MR/K006665/1). A. Custovic has received personal fees from Novartis, Thermo Fisher, AstraZeneca, ALK-Abelló, and GlaxoSmithKline. I. E. Buchan's institution has received funding from the Medical Research Council, as has that of M. C. F. Prosperi. D. Belgrave is an employee of GlaxoSmithKline. A. Simpson's institution has received funding from the Medical Research Council, the JP Moulton Charitable Foundation, the North West Lung Centre Charity, the European Union, and the National Institute of Health Research; she has received consultancy fees from Thermo Fisher Scientific and has received payment for delivering lectures from GlaxoSmithKline and Chiesi and has received compensation for travel and other meeting-related expenses from GlaxoSmithKline. H.-J. Sonntag declares that he has no other relevant conflicts of interest. |
Vol 136 - N° 6
P. 1645 - décembre 2015 Retour au numéro
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