Mechanisms of Aeroallergen Immunotherapy : Subcutaneous Immunotherapy and Sublingual Immunotherapy - 27/11/15
Résumé |
Allergen immunotherapy (AIT) is an effective way to treat allergic disorders, targeting the underlying mechanisms and altering the disease course by inducing a long-lasting clinical and immune tolerance to allergens. Although sublingual and subcutaneous routes are used in daily practice, many novel ways to decrease side effects and duration and increase efficacy have been pursued. Further studies are needed to develop biomarkers for the identification of AIT responder patients and also to use the developed knowledge in allergy prevention studies. Future directions in AIT include treatments for autoimmune diseases, chronic infections, organ transplantation, and breaking immune tolerance to cancer cells.
Le texte complet de cet article est disponible en PDF.Keywords : Allergy, Allergens, Immunotherapy, T regulatory cells, Tolerance
Plan
Conflict of Interest: C.Ozdemir and U.C. Kuzuksezer declare no conflict of interest. M. Akdis has received research support from the Swiss National Science Foundation and the European Commission's Seventh Framework Programmes MeDALL and PREDICTA. C.A. Akdis has consultant arrangements with Actellion, Aventis, Stallergenes, Allergopharma, and Circacia; is employed by the Swiss Institute of Allergy and Asthma Research, University of Zurich; and has received research support from Novartis, PREDICTA: European Commission's Seventh Framework, the Swiss National Science Foundation, MeDALL: European Commission's Seventh Framework, and the Christine Kühne-Center for Allergy Research and Education. The authors' laboratories are supported by the Swiss National Science Foundation No. 310030_156823, 320030-159870, and Christine Kühne-Center for Allergy Research and Education (CK-CARE). |
Vol 36 - N° 1
P. 71-86 - février 2016 Retour au numéroBienvenue sur EM-consulte, la référence des professionnels de santé.
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