Allergen Immunotherapy Outcomes and Unmet Needs : A Critical Review - 27/11/15

Doi : 10.1016/j.iac.2015.08.011

Davide Caimmi, MD ^a,^b, Moises A. Calderon, MD, PhD ^c, Jean Bousquet, MD, PhD ^b, Pascal Demoly, MD, PhD ^a,^d,^⁎
^a Division of Allergy, Department of Pulmonology, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, 371, av. du Doyen Gaston Giraud – 34295, Montpellier cedex 5, France
^b MACVIA-LR, European Innovation Partnership on Active and Healthy Ageing Reference Site, University Hospital of Montpellier, 371, av. du Doyen Gaston Giraud – 34295, Montpellier cedex 5, France
^c Section of Allergy and Clinical Immunology, Imperial College London, National Heart & Lung Institute, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
^d Sorbonne Universités, UPMC Paris 06, UMR-S 1136, IPLESP, Equipe EPAR, F-75013, 4, Place Jussieu – 75005 Paris, France

^∗Corresponding author. Division of Allergy, Department of Pulmonology, Hôpital Arnaud de Villeneuve, 371, Av du Doyen Gaston Giraud, Montpellier 34090, France.

Résumé

Allergen immunotherapy (AIT) has been evaluated throughout several studies over the last years. A position paper from the European Academy of Allergy and Clinical Immunology highlighted the total combined symptoms score as the method to record the primary end point in AIT studies for allergic rhinitis, but this score still needs to be formally validated and more work done for other allergic diseases. These aspects still seem to be the main unmet need in the evaluation of AIT clinical outcomes in clinical trials.

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Keywords : Allergen immunotherapy (AIT), Allergic rhinitis, Clinical outcomes, Primary end point, Unmet needs

Plan

Cost-effectiveness of allergen immunotherapy

Unmet needs

Summary

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Disclosure: See last page of article.

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Vol 36 - N° 1

P. 181-189 - février 2016 Retour au numéro

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Allergen Immunotherapy Outcomes and Unmet Needs : A Critical Review - 27/11/15

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