Breast-feeding does not protect against allergic sensitization in early childhood and allergy-associated disease at age 7 years - 06/11/15
Abstract |
Background |
Extended breast-feeding is recommended for newborn children at risk of allergy-associated diseases, but the evidence of a protective effect on sensitization and these diseases remains elusive.
Objective |
The aim of this study was to investigate the effects of the duration of exclusive breast-feeding on the development of sensitization in preschool children.
Methods |
Information on breast-feeding was gathered by interviews involving 335 children aged 1, 6, and 12 months from the Copenhagen Prospective Study on Asthma in Childhood2000 birth cohort born to mothers with a history of asthma. Skin prick test responses and specific IgE levels against 12 common inhalant and 10 food allergens were assessed longitudinally at ages ½ year, 1½ years, 4 years, and 6 years. Eczema, wheeze/asthma, and allergic rhinitis were diagnosed at the Copenhagen Prospective Studies on Asthma in Childhood clinic at 7 years of age, strictly adhering to predefined algorithms. Associations between duration of exclusive breast-feeding and outcomes were analyzed by logistic regression.
Results |
We found no significant association between duration of exclusive breast-feeding and development of sensitization in the first 6 years of life (odds ratio [OR]: ½ year, 1.10 [95% CI, 0.90-1.36]; 1½ years, 1.15 [95% CI, 0.97-1.36]; 4 years, 1.08 [95% CI, 0.93-1.25]; and 6 years, 0.96 [95% CI, 0.84-1.10]) or with current eczema, wheeze/asthma, and allergic rhinitis at age 7 years (OR, 1.07 [95% CI, 0.92-1.24]; OR, 0.97 [95% CI, 0.82-1.14]; and OR, 1.02 [95% CI, 0.84-1.23], respectively). Adjusting for reverse causation by excluding children with eczema, wheeze, or a positive skin prick test response before ending exclusive breast-feeding did not alter the results.
Conclusion |
Exclusive breast-feeding does not affect sensitization in early childhood or associated diseases at 7 years of age in at-risk children.
Le texte complet de cet article est disponible en PDF.Key words : Breast-feeding, sensitization, asthma, eczema, skin prick test, specific IgE, children
Abbreviations used : COPSAC, IHRP, OR, sIgE, SPT
Plan
| The Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) is funded by private and public research funds, all of which are listed at www.copsac.com. The Lundbeck Foundation (R16-A1694); the Ministry of Health (grant no. 903516); the Danish Council for Strategic Research (grant no. 0603-00280B); the Danish Council for Independent Research (grant no. 10-082884; 271-08-0815); and the Capital Region Research Foundation have provided core support for COPSAC. Thermo Fisher Scientific Inc sponsored the IgE analyses. No pharmaceutical company was involved in the study. The funding agencies did not have any role in design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript. |
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| Disclosure of potential conflict of interest: H. Bisgaard has received research support from the Lundbeck Foundation, the Danish Ministry of Health, and the Danish Strategic Research Foundation. The rest of the authors declare that they have no relevant conflicts of interest. |
Vol 136 - N° 5
P. 1302 - novembre 2015 Retour au numéro
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