We report the constitutional resolution and selection of the dynamic supramolecular guanosine systems by using a kinetically irreversible polymerization process.

We report an original strategy to transcribe and to fix supramolecular guanosine architectures in self-organized polymers. In the first resolution step, the G-quartet and G-quadruplex architectures are pre-amplified in solution in the presence of K⁺ cations from a dynamic pool of ribbon-type or cyclic supramolecular architectures. Then in a second selection polymerization step, the G-quadruplex is kinetically fixed in a covalent polymethacrylate network via an irreversible amplification step. Both supramolecular and polymeric components mutually (synergistically) adapt their spatial constitution during simultaneous (collective) formation of micrometric self-organized hybrid domains. This contributes to the high level of adaptability and correlativity of the self-organization of the supramolecular G-quadruplexes and of the polymeric systems. Biomimetic-type hybrid systems can be generated by using this strategy.