Polyaniline/CoFe₂O₄ nanocomposite inhibits the growth of Candida albicans 077 by ROS production - 26/09/13

Doi : 10.1016/j.crci.2013.08.006

Javed Alam Khan ^a,^{^{1
These authors contributed equally.}}, Mohd Qasim ^b,^{^{1
These authors contributed equally.}}, Braj Raj Singh ^a,^⁎ , Wasi Khan ^a, Dibakar Das ^b, Alim H. Naqvi ^a
^a Centre of Excellence in Materials Science (Nanomaterials), Department of Applied Physics, Z.H. College of Engineering and Technology, Aligarh Muslim University, Aligarh 202002, UP, India
^b School of Engineering Sciences and Technology (SEST), University of Hyderabad, Hyderabad 500 046, AP, India

^⁎Corresponding author.

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Abstract

In recent years, polyaniline/CoFe₂O₄ nanocomposites have gained attention because of their wide utilization in optoelectronics and biomedical studies. However, very limited research has been carried out on the anticandidal activity of polyaniline/CoFe₂O₄ nanocomposite against Candida spp. Thus, the study was designed to investigate the anticandidal potential of PANI/CoFe₂O₄ nanocomposite against Candida albicans 077. PANI/CoFe₂O₄ nanocomposite (denoted as “cfPNCs”) was synthesized by polymerization of aniline in the presence of CoFe₂O₄ nanoparticles. The structural and thermal properties of the synthesized PANI/CoFe₂O₄ nanocomposite were investigated. It was noteworthy that PANI/CoFe₂O₄ nanocomposite showed promising anticandidal activity in a dose-dependent manner. Results also showed that the protection of histidine (a ROS quencher) against ROS clearly suggested the implication of ROS in anticandidal activity of PANI/CoFe₂O₄ nanocomposite. It is encouraging to conclude that PANI/CoFe₂O₄ nanocomposite bears the potential of their applications in biomedicine, especially nanotherapy for diseases caused by C. albicans.