The efficacy of B-type natriuretic peptide for early identification of blood loss in traumatic injury - 19/08/11
, Greg Rimmer, D.O. b, Taylor MacDonald, M.S. c, Kimberly Barber, Ph.D. c, Patricia Manion, R.N., M.S. d, Brian Shapiro, M.D. d : F.A.C.S., John Socey, D.O. a : F.A.C.S., Douglas Iddings, D.O. a
Corresponding author. Tel.: +1-810-606-5000.Abstract |
Background |
Because B-type natriuretic peptide (BNP) secretion has a direct linear correlation with intravascular volume status, it was assessed as an initial marker for blood loss (BL) in polytrauma patients.
Methods |
Hemodynamically unstable trauma patients between 18 and 45 years had serial BNP levels and hemoglobin (Hgb) levels obtained on admission, at 8 and 24 hours, and every morning during resuscitation.
Results |
The 14 patients were categorized into 2 groups based on the 24-hour trend in Hgb levels: clinically significant blood loss (Hgb decrease >3 g/dL) or no clinical blood loss (Hgb decrease <3 g/dL). On admission, the 5 patients in the no blood loss group had normal BNP levels, whereas the 9 patients in the BL group had below-normal BNP levels. Because patients in the BL category were resuscitated, their BNP levels normalized.
Conclusions |
BNP levels below normal are indicative of intravascular volume loss in traumatically injured patients.
Le texte complet de cet article est disponible en PDF.Keywords : Blood loss, B-type natriuretic peptide, Trauma
Plan
Vol 191 - N° 3
P. 353-357 - mars 2006 Retour au numéro
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