Vitamin D and the vitamin D receptor in liver pathophysiology - 20/04/11
Corresponding author. UPMC, UMR_S 938, CdR Saint-Antoine, 27, rue de Chaligny, 75571 Paris cedex 12, France. Tel.: +33 1 40 01 13 56; fax: +33 1 40 01 14 26.
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Summary |
Vitamin D through the vitamin D nuclear receptor (VDR) plays a key role in mineral ion homeostasis. The liver is central in vitamin D synthesis, however the direct involvement of the vitamin D-VDR axis on the liver remains to be evaluated. In this review, we will describe vitamin D metabolism and the mechanisms of homeostatic control. We will also address the associations between the vitamin D-VDR axis and pathological liver entities, such as non-alcoholic fatty liver disease, autoimmune liver disease, viral hepatitis and liver cancer. The link between liver diseases and the vitamin D-VDR axis will be discussed in light of evidences arising from in vitro and in vivo studies. Finally, we will consider the therapeutic potential of the vitamin D-VDR axis in liver diseases.
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Vol 35 - N° 4
P. 295-302 - avril 2011 Retour au numéro
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