N012 Endovascular gingival fibroblast cell therapy reduced the size of aneurysms in a rabbit model of elastase-induced carotid injury - 17/04/09
Résumé |
Background |
Aortic abdominal aneurysm is characterized by excessive enlargement remodeling secondary to medial elastin destruction, and the severity of the disease has been correlated with metalloproteinase-9 (MMP-9). We aimed to evaluate whether embryo-like healing potential of a tissue (i.e., the gum) could be transposed to another tissue (i.e., the artery wall).
Methods and Results |
Porcine pancreatic elastase was incubated during 15minutes in rabbit carotid arteries (n=30). Four to 6 weeks later, carotid arteries were seeded endoluminally at the site of aneurysm with either rabbit gingival fibroblasts (n=12) or culture medium only which served as control (n=11). Vessel diameter and elastin density were assessed 4 weeks after cell therapy. Carotid diameter was similar before cell therapy in both group (3.4±0.5mm vs 3.1±0.37mm, p=0.30). In contrast, carotid diameters were significantly decreased in aneurismal arteries seeded with rabbit gingival fibroblasts as compared to control aneurismal arteries (2.7±0.64mm vs 3.60±0.52, p=0.003). Moreover, elastin density was significantly higher in the media after endovascular gingival fibroblast than in controls (32.5±4.7 % vs 14.3±8.2 %, p=0.001). Four weeks after cell transplantation, gingival fibroblasts inhibited MMP-9 secretion via a significant increase of its inhibitor, TIMP-1.
Conclusions |
Endovascular gingival fibroblast cell therapy improved elastin network and reduced the size of aneurysms in a rabbit model. This strategy may be attractive since gingival fibroblast are easily accessible are known to safely proliferate in culture medium.
Le texte complet de cet article est disponible en PDF.Vol 102 - N° S1
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