Early-onset childhood atopic dermatitis is related to NLRP2 repression - 12/01/18

Doi : 10.1016/j.jaci.2017.11.018

Loreen Thürmann, PhD ^a,^{^{∗
These authors contributed equally to this work.}}, Konrad Grützmann, PhD ^a,^b,^{^{∗
These authors contributed equally to this work.}}, Matthias Klös, MSc ^a, Matthias Bieg, MSc ^c,^d, Marcus Winter, MSc ^a, Tobias Polte, PhD ^a, Tobias Bauer, PhD ^c, Matthias Schick, Dipl-Ing ^e, Melanie Bewerunge-Hudler, PhD ^e, Stefan Röder, PhD ^a, Mario Bauer, MD ^a, Dirk K. Wissenbach, PhD ^f,^g, Ulrich Sack, PhD ^h, Dieter Weichenhan, PhD ⁱ, Oliver Mücke ⁱ, Christoph Plass, PhD ⁱ, Michael Borte, MD ^j, Martin von Bergen, PhD ^f,^k, Irina Lehmann, PhD ^a,^{^{∗
These authors contributed equally to this work.}} , Roland Eils, PhD ^c,^d,^l,^m,^{^{∗
These authors contributed equally to this work.}}, Saskia Trump, PhD ^a,^{^{∗
These authors contributed equally to this work.}}
^a Department of Environmental Immunology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany
^f Department of Molecular Systems Biology, Helmholtz Centre for Environmental Research Leipzig, Leipzig, Germany
^b Center for Molecular Tumor Diagnostics at the National Center for Tumor Diseases, partner site Dresden, Dresden, Germany
^c Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany
^d Heidelberg Center for Personalized Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany
^e Genomics and Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany
ⁱ Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany
^g Institute of Forensic Medicine, University Hospital Jena, Jena, Germany
^h Institute of Clinical Immunology, University Hospital Leipzig, Leipzig, Germany
^j Municipal Hospital “St. Georg” Children's Hospital, Leipzig, Germany
^k Department of Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, University of Leipzig, Leipzig, Germany
^l Institute of Pharmacy and Molecular Biotechnology, and Bioquant Center, University of Heidelberg, Heidelberg, Germany
^m Translational Lung Research Center Heidelberg, German Center for Lung Research, University of Heidelberg, Heidelberg, Germany

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This work was supported by the Helmholtz Initiative on Personalized Medicine (iMed) and the Helmholtz Interdisciplinary Graduate School for Environmental Research (HIGRADE). S. Trump was supported by the Federal Ministry of Education and Research (BMBF) grant 01ZX1402D.

Disclosure of potential conflict of interest: T. Bauer receives support from a grant from BioMedX; and support from BMBF for travel to meetings for the study or other purposes; fees for participation in review activities such as data monitoring boards; statistical analysis, end point committees, and the like; and payment for writing or reviewing the manuscript. D. Weichenhan declares employment from DKFZ Heidelberg. C. Plass receives consultancy fees from BioMedX. All other authors declare that they have no relevant conflicts of interest.

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Early-onset childhood atopic dermatitis is related to NLRP2 repression - 12/01/18

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